Oxidative stress

Oxidative stress reflects an imbalance between the production of reactive oxygen species (ROS) and a biological system's ability to neutralize these toxic molecules and to repair the resulting damage. The causes of toxic oxygen properties were unknown since the publication of the theory of Gershman et al in 1954, whereby oxygen toxicity is due to partially reduced forms of oxygen.

The presence of reactive oxygen species in biological materials was described for the first time about 50 years ago. Later, Denham Harman formulated the hypothesis that oxygen radicals can be produced in vivo as by-products of biological reactions. In 1956, he described the reactive radicals as evil contents of Pandora's box, responsible for cell injury, mutagenicity, cancer, degenerative biological aging processes.

Oxidative stress factors

The oxidative stress factors are classified into the following four categories; free radicals, ions, combinations among ions, and molecules.

Free radicals, which are characterised by an unpair electron in their outer layer, are very unstable molecules. They react directly with adjacent molecules, stealing an electron from them. Adjacent molecules thereby are converted into free radicals, and thus a chain reaction begins that leads to cell damage.

Some of the less reactive forms, such as peroxides, can be converted, upon reaction with transition elements or quinones, into more aggressive, such as to cause extensive cell damage.

The long-term cellular damage caused, mainly attacks the DNA.

Consequences of Oxidative Stress

The various factors that are implicated in cardiovascular diseases (smoking, increased cholesterol, diabetes mellitus, ypertirichaimia) are associated with oxidative stress.

Oxidative stress is implicated in the pathophysiology of:

  • atherosclerosis
  • coronary disease
  • heart failure

Oxidative stress is implicated in the pathophysiology of:

  • diabetes
  • arterial hypertension
  • Alzheimer's disease
  • Parkinson's disease
  • pancreatitis
  • non-alcoholic liver steatonekrosis
  • preeclampsia
  • rheumatoid arthritis
  • acquired immune deficiency syndrome (AIDS)

The inflammation processes, some cases of carcinogenicity, even the normal aging process, have been attributed to production of oxygen free radicals. In addition, medicine's side effects have been attributed to oxidative stress.

In generally it appears that the cell response to stress occurs during the disease, and as a logical thought is to influence the course of disease.

Oxidative stress treatment

To prevent harm to our health from the overproduction of free radicals, it is particularly important to investigate the levels of oxidative stress that exists in our body.

This can be achieved through a special examination, which can evaluate both the oxidation state, ie the amount of free radicals produced in the body, and the antioxidant capacity of the body, ie the body's ability to neutralize free radicals in the their production before damaging the cells. The measurement is done with capillary blood, ie taking blood from the finger through the internationally recognized d-ROMs and BAP tests. The examination of oxidative stress is a revolutionary new indicator for health. Proper interpretation helps us to take timely measures to prevent and treat many diseases associated with increased oxidative stress.

Whom it may concern?

The test to measure oxidative stress concern:

  • Healthy people to detect the underlying oxidative stress before it causes cell damage (premature aging, disease) and addressed.
  • Patients who follow this treatment in order to assess the progress of treatment and disease progression.
  • Pregnant and athletes, ie people in special circumstances with increased nutritional requirements, which the frequent assessment of oxidative stress is essential in order not damaged the body. Oxidative stress represents an imbalance between the production of ROS (Reactive Oxygen Species, ROS) and the capacity of a biological system to neutralize these toxic molecules and to repair the damage caused. The active oxygen species damage all cell components, including proteins, lipids and DNA.